The MFG group looks to develop new methods that enable faster, cleaner and better synthesis. We then apply these methods to the construction of complex molecule targets that have interesting biological roles and functions. These targets are usually drawn from natural product or medicinal chemistry. Finally, we look to apply our core expertise in synthetic chemistry to problems at the interface of chemistry and biology.

SELECTED RECENT PUBLICATIONS

1. Douelle, F.; Capes, A. S.; Greaney, M. F. 'Highly diastereoselective synthesis of vicinal quaternary and tertiary stereocentres using the iodo-aldol cyclisation' Org. Lett., 2007, 9, 1931-1934.
2. Shi, B.; Stevenson, R.; Campopiano, Dominic J.; Greaney, Michael F. ‘Discovery of Glutathione S-Transferase Inhibitors Using Dynamic Combinatorial Chemistry’. J. Am. Chem. Soc., 2006, 128, 8459-8467.
3. Henderson, J. L.; Edwards, A. S.; Greaney, M. F. ‘Three-Component Coupling of Benzyne: Domino Intermolecular Carbopalladation’. J. Am. Chem. Soc., 2006, 128, 7426 – 7427.
4. Ferrer Flegeau, E.; Popkin, M. E.; Greaney, M. F. ‘Suzuki Coupling of Oxazoles’ Org Lett., 2006, 8, 2495 – 2498.
5. Iriondo-Alberdi, J.; Perea-Buceta, J.; Greaney, M. F. ‘A Paternò-Büchi approach to the synthesis of merrilactone A’. Org Lett., 2005, 7, 3969-3971.