We have research projects in bioinorganic, supramolecular
and materials chemistry. In bioinorganic chemistry we are interested in
synthetic modeling chemistry, biocatalysis, biological imaging and medicinal
chemistry. In supramolecular/materials chemistry our work is concerned
with molecular recognition via hydrogen bonding, self-assembled monolayers
(SAMs) and semiconductor nanoparticles (quantum dots). Current projects
- Artificial phosphate ester binding and cleavage. We have prepared
ZnII complexes of ligands with H-bonding groups that are exceptionally
effective for recognizing and cleaving phosphate esters. These complexes
open now the possibility of creating agents for effective and selective
cleavage of DNA/RNA under mild physiological conditions with the potential
for applications in biotechnology and medicinal chemistry.
- Catalytic and sensing SAMs. We are using SAMs on electrodes for redox-mediated
catalysis and sensing. Some of the chemistry involves reduction/oxidation
of small molecules e.g. O2, N2, NOx, ClOx etc., and sensing toxic or
important molecules and ions e.g. metals, cyanide, phosphates, proteins,
nucleic acids etc.
- Quantum dots interacting with metal complexes. We are preparing fluorescent
nanoparticles in which the interaction with metals or complexes is exploited
for in vivo and in vitro biological imaging and generation of photocurrents.
DNA cleaving agent
Measuring the rate of ET across SAMs
SELECTED RECENT PUBLICATIONS
- Relative importance of H-bonding and co-ordinating groups in modulating
the zinc-water acidity J. C. Mareque-Rivas, R. Prabaharan, R. Torres
Martin de Rosales, Chem. Commun. 2004, 76.
- Structures and reactivity of synthetic zinc(II) complexes resembling
the active sites and reaction intermediates of aminopeptidases”
J. C. Mareque-Rivas, E. Salvagni, S. Parsons, Chem. Commun.
- The affinity of phosphates to zinc(II) complexes can be improved
with H-bond donors J. C. Mareque-Rivas, R. Torres Martin de Rosales,
S. Parsons, Chem. Commun, 2004, 610.
- A Highly Reactive Mononuclear Zn(II) Complex for Phosphodiester
Cleavage G. Feng, J. C. Mareque-Rivas, R. Torres Martin de Rosales,
N. H. Williams, J. Am. Chem. Soc, 2005, 127(39),13470.
- A comparison between mononuclear Zn(II) complexes with H-bond donors
and dinuclear Zn(II) complexes for catalyzing phosphate ester cleavage
G. Feng, J. C. Mareque-Rivas, N.H. Williams, Chem. Commun.
- H-Bonding Cavities Regulating Redox Behaviour and Binding of Metal-Bound
Ligands L. Metteau, S. Parsons, J. C. Mareque-Rivas, Inorg. Chem.
2006, 45, 6601.
- The strength of H-bonding interactions to metal bound ligand can
contribute to changes in the redox behavior of metal centres J. C.
Mareque-Rivas, S. L. Hinchley, L. Metteau, S. Parsons, Dalton Trans.
- Efficient phosphodiester binding and cleavage by a ZnII
complex combining H-bonding interactions and double Lewis acid activation
G. Feng, J. C. Mareque-Rivas, D. Natale, R. Prabaharan, N. H. Williams,
Angew Chem. Int. Ed. 2006, 45, 7056.
- Metal-mediated transport of electrons across molecular films V.
Ganesh, P. Calatayud, J. C. Mareque-Rivas, Chem. Commun. 2007,